01788nas a2200313   4500000000100000008004100001260001300042653001000055653001800065653004400083653001600127653003100143653001100174653002300185653002000208653001200228653002200240653001800262653002000280100001300300700001200313700001500325700001100340245012900351300001000480490000700490520096300497022001401460       1980                            d  c1980 Oct10aAdult10aB-Lymphocytes10aDose-Response Relationship, Immunologic10aFetal Blood10aGastrointestinal Neoplasms10aHumans10aImmunity, Cellular10aInfant, Newborn10aleprosy10aRosette Formation10aT-Lymphocytes10aThymus Extracts1 aShoham J1 aCohen M1 aChandali Y1 aAvni A00aThymic hormonal activity on human peripheral blood lymphocytes, in vitro. I. Reciprocal effect on T and B rosette formation.  a353-90 v413 a<p>One hour incubation with the thymic extract TP-1 induced reciprocal effect on B and T rosette formation in lymphocytes of human peripheral blood. The percentage of mouse erythrocyte rosette-forming cells among lymphocytes of chronic lymphatic leukaemia was decreased by TP-1 from 54.5% to 27.1% (P < 0.001). No such effect was observed in healthy adult or cord blood lymphocytes. On the other hand, the percentage of sheep erythrocyte rosette forming cells increased significantly after TP-1 treatment, but only under conditions of active rosette formation and not in the total rosette assay. This increase was highly significant in three conditions with relative deficiency of cell-mediated immunity: newborns (17.1 to 28.3%), cancer patients (24.5 to 31.7%) and patients with lepromatous leprosy (19.8 to 31.8%). Only a small increase was noticed in healthy adults. A similarly prepared spleen extract was not active in either B or T rosette assays.</p>  a0019-2805