02073nas a2200337   4500000000100000008004100001260000900042653003400051653002000085653002300105653001600128653001100144653003700155653002900192653002900221653002000250653001200270653003400282653001300316653002300329653002200352653001900374653001800393100001300411700001300424245005100437300001100488490000600499520121600505022001401721       1981                            d  c198110aAnemia, Hemolytic, Autoimmune10aChronic Disease10aGlomerulonephritis10aHepatitis B10aHumans10aImmunologic Deficiency Syndromes10aImmunosuppressive Agents10aInfectious Mononucleosis10aKidney Diseases10aleprosy10aLupus Erythematosus, Systemic10aLymphoma10aMultiple Sclerosis10aMyasthenia Gravis10aSkin Neoplasms10aT-Lymphocytes1 aBach M A1 aBach J F00aImbalance in T cell subsets in human diseases.  a269-730 v33 a<p>T cell subsets have been evaluated in 232 patients with various immunological diseases and 41 normal individuals used as a control group. An increase in the helper/suppressor ratio (OKT4:OKT8) was often noted in multiple sclerosis (acute attacks and progressive forms), autoimmune hemolytic anemia (without steroids), membranous and IgA-deposit glomerulonephritis, HBs-negative chronic active hepatitis, lepromatous patients with erythema nodosum, and myasthenia gravis. Ratios were usually normal in membranoproliferative nephritis, in lupus erythematosus (at least in steroid treated cases) and in nephrotic syndrome. High values of helper cells have been found in Sezary's syndrome (with low or no suppressor cells) and in mycosis fungoides. Variable data have been obtained in immunodeficiency syndromes. These data have been correlated with age, sex and clinical parameters, as well as with other immunological tests (E rosettes, mitogen responses, mixed lymphocyte reaction, Concanavalin A-induced suppression). From our investigations we have concluded that the study of OKT antibody-defined T cell subsets offers a valuable technique for the further investigation of human immunological diseases.</p>  a0192-0561