01595nas a2200277   4500000000100000008004100001260001300042653002800055653002900083653001900112653003100131653001100162653002000173653001200193653002500205653002200230653000900252100001300261700001200274245005600286856004100342300001200383490000700395520090100402022001401303       1981                            d  c1981 Sep10aAntibodies, Antinuclear10aAntigen-Antibody Complex10aAutoantibodies10aComplement System Proteins10aHumans10aImmunoglobulins10aleprosy10aPlatelet Aggregation10aRheumatoid Factor10aSkin1 aSehgal S1 aKumar B00aCirculating and tissue immune complexes in leprosy.  uhttp://ila.ilsl.br/pdfs/v49n3a02.pdf  a294-3010 v493 a<p>Various immunological studies were conducted in lepromatous leprosy patients. There was a polyclonal rise of all the three major immunoglobulins. Serum IgD levels remained unaltered. Positive latex agglutination reactions (RA) and parietal cell antibodies were distinctly more frequent in patients. Eighty-five percent of patients showed a strongly positive complement deviation test, and the mean platelet aggregation titer was 1 in 81 in the patients compared to 1 in 3 in the controls, thus indicating the presence of circulating immune complexes in a large percentage of cases. Immunoglobulins and complement were observed in the dermal capillaries and small arterioles, but not in larger vessels, in 6 of 17 cases. Only one case showed staining of the dermoepidermal junction. Antinuclear antibodies (ANA) were detected in a single patient, and this patient also showed ANA in vivo.</p>
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