01349nas a2200337 4500000000100000008004100001260001300042653001000055653000900065653001900074653001700093653004100110653003100151653001100182653001000193653001200203653001600215653002900231653004500260653001400305100001500319700001100334700001200345700001500357700001600372245004500388300001000433490000700443520054700450022001400997 1981 d c1981 Nov10aAdult10aAged10aGene Frequency10aHLA Antigens10aHistocompatibility Antigens Class II10aHistocompatibility Testing10aHumans10aJapan10aleprosy10aMiddle Aged10aMycobacterium Infections10aMycobacterium Infections, Nontuberculous10aPhenotype1 aMiyanaga K1 aJuji T1 aMaeda H1 aNakajima S1 aKOBAYASHI S00aTuberculoid leprosy and HLA in Japanese. a331-40 v183 a
HLA phenotypes of 54 patients with tuberculoid leprosy were compared with those of 167 healthy controls. Frequencies of HLA-A, -B and -C antigens did not differ significantly between the leprosy patients and the controls. However, an increase in the frequencies of DR1, DR2, DRW8 and MT1 antigens and a decrease in the frequencies of DR4 and MT3 antigens were observed in the leprosy patients. Statistical evidence was presented that MT1 antigens were primarily associated with tuberculoid leprosy in Japanese patients rather than DR2.
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