01213nas a2200253   4500000000100000008004100001260000900042653001700051653004100068653003100109653001100140653001000151653001200161653001400173100001200187700001500199700001600214700001300230245009300243300001000336490000700346520059200353022001400945       1982                            d  c198210aHLA Antigens10aHistocompatibility Antigens Class II10aHistocompatibility Testing10aHumans10aJapan10aleprosy10aPhenotype1 aIzumi S1 aSugiyama K1 aMatsumoto Y1 aOhkawa S00aAnalysis of the immunogenetic background of Japanese leprosy patients by the HLA system.  a243-70 v423 a<p>295 lepromatous and 74 tuberculoid leprosy patients were typed for HLA-A, -B and -C and compared to 110 healthy controls. It was found that frequency of HLA-B7 was significantly high and that of Bw54 was significantly low in lepromatous leprosy. HLA-DR and MT types were investigated in 84 lepromatous and 28 tuberculoid patients and compared to 55 controls. Both lepromatous and tuberculoid patients showed a marked increase in DR2 frequency. The relative risk is 8.7 and 5.9. Lepromatous leprosy showed an increase in frequency of MT1 and decreases in those of DRw9 and MT3 too.</p>  a0042-9007