01601nas a2200325   4500000000100000008004100001260001300042653001500055653001000070653000900080653001100089653001100100653002300111653001200134653000900146653001600155653002200171653001800193100001200211700001200223700001300235700001200248700001200260700001500272245005700287300001100344490000700355520089900362022001401261       1982                            d  c1982 Oct10aAdolescent10aAdult10aAged10aFemale10aHumans10aImmunity, Cellular10aleprosy10aMale10aMiddle Aged10aRosette Formation10aT-Lymphocytes1 aLim S D1 aWoo C S1 aYoun J I1 aKim Y W1 aKim D I1 aFUSARO R M00aLeprosy. XII. T-cell subsets in lepromatous leprosy.  a458-640 v213 a<p>The authors quantitated T-rosette-forming cell (TRFC) and T-cell subsets (T mu, T gamma) in the peripheral blood of twenty patients with lepromatous leprosy. The results obtained in their studies are as follows: (1) They reconfirmed the low levels of TRFC in patients with lepromatous type of leprosy; (2) T-cell subsets, both T mu (helper) and T gamma (suppressor) cells, showed lower levels in all patients with lepromatous leprosy than mean values of normal healthy controls; (3) The degree of decreased levels of T mu cells (96%) was more severe than other parameters TRFC (70%) and T gamma cells (47%) in all patients with lepromatous leprosy; and (4) It may be concluded that the alteration of the T-cell subset, T mu-cells, reflects a more fundamental abnormality than TRFC aberration in demonstrating the impairment of cell-mediated immunity in patients with lepromatous leprosy.</p>  a0011-9059