01232nas a2200313   4500000000100000008004100001260001300042653001000055653001200065653002100077653001100098653001100109653001300120653001200133653001600145653000900161653001600170653001300186653002600199653000900225653001600234100001200250700001400262245006700276300001100343490000800354520054200362022001400904       1978                            d  c1978 Jul10aAdult10aDapsone10aErythema Nodosum10aFemale10aHumans10aIschemia10aleprosy10aLymphopenia10aMale10aMiddle Aged10aNecrosis10aRetrospective Studies10aSkin10aThalidomide1 aRea T H1 aLevan N E00aLucio's phenomenon and diffuse nonnodular lepromatous leprosy.  a1023-80 v1143 a<p>The records of ten patients with Lucio's phenomenon showed clinical and histopathological changes similar to those described by others. Lucio's phenomenon is a syndrome distinct from erythema nodosum leprosum as indicated by an absence of fever, leukocytosis and tenderness, a failure to respond to thalidomide, and a restriction to patients with diffuse nonnodular lepromatous leprosy. Lymphopenia associated with splenomegaly in three patients and glomerulonephritis in one patient were unexpected findings of unknown relevance.</p>  a0003-987X