01241nas a2200253   4500000000100000008004100001260001300042653001200055653001800067653001600085653001200101653000900113653002100122653002500143653001800168100001300186700001500199245008200214300000900296490000700305050003200312520062900344022001400973       1983                            d  c1983 Jan10aAnimals10aBlood Vessels10aEndothelium10aleprosy10aMice10aMice, Inbred CBA10aMicroscopy, Electron10aSciatic Nerve1 aBhat K R1 aVaidya M C00aVascular changes in nerves in experimental leprosy--an ultrastructural study.  a60-30 v55  aInfolep Library - available3 a<p>Ultrastructural observations made on the blood vessels of nerves in CBA/J mice with experimentally produced M. leprae infection revealed cytoplasmic filamentous structures along with large sized vacuoles in the endothelial cells and reduplication of peripericytal basement membranes in the 6-9 months of infection. In animals with late infection of 9-15 months duration, the endothelial cells presented foamy appearance caused by an increase in the number of vacuoles. These findings are suggestive of degenerative changes in the endothelial cells probably due to circulation of noxious substance in the blood stream.</p>  a0024-1024