02024nas a2200361   4500000000100000008004100001260001300042653002900055653001200084653001800096653001100114653002000125653000900145653001000154653001400164653001500178653001200193653001600205653001400221653001800235653001300253653002100266653001000287653001900297100001700316700001500333700001500348245012600363300001100489490000700500520114100507022001401648       1983                            d  c1983 May10aAnimal Population Groups10aAnimals10aAnimals, Wild10aCattle10aCattle Diseases10aDeer10aGoats10aGranuloma10aIntestines10aleprosy10aLymph Nodes10aMesentery10aMycobacterium10aNecrosis10aParatuberculosis10aSheep10aSheep Diseases1 aWilliams E S1 aSnyder S P1 aMartin K L00aPathology of spontaneous and experimental infection of North American wild ruminants with Mycobacterium paratuberculosis.  a274-900 v203 a<p>Spontaneous paratuberculosis was studied in free-ranging and captive bighorn sheep (Ovis canadensis), and Rocky Mountain goats (Oreamnos americanus). Lesions of paratuberculosis in these species resembled the disease in domestic sheep and goats. Mycobacterium paratuberculosis cultured from bighorn sheep was used to orally infect bighorn x mouflon (Ovis musimon) hybrid sheep, elk (Cervus elaphus nelsoni), mule deer (Odocoileus hemionus), and white-tailed deer (Odocoileus virginianus). Clinical paratuberculosis developed only in mule deer and was characterized by poor growth and diarrhea. Gross lesions were mild in all species. Enlargement of mesenteric lymph nodes was mild to moderate; the wall of the distal small intestine was affected minimally. Focal to diffuse infiltrates of epithelioid macrophages and giant cells occurred in the cortex of mesenteric lymph nodes, around mesenteric lymphatics, and in the intestinal mucosa. Extraintestinal lymph nodes, spleen, liver, and lung were involved in some animals; focal necrosis and mineralization was present in all species but was severe and widespread in the cervids.</p>  a0300-9858