01453nas a2200361   4500000000100000008004100001260001300042653001500055653001000070653003000080653001500110653001400125653001900139653002000158653001100178653002800189653001100217653001200228653001000240653000900250653001600259100001200275700001500287700001200302700001500314700001100329245006700340300001000407490000700417050003200424520062100456022001401077       1982                            d  c1982 Jan10aAdolescent10aAdult10aAminopyrine N-Demethylase10aAntipyrine10aBilirubin10aBiopsy, Needle10aChloramphenicol10aFemale10aGlucuronosyltransferase10aHumans10aleprosy10aLiver10aMale10aMiddle Aged1 aKumar B1 aNarang A P1 aKoshy A1 aSharma S C1 aKaur S00aIn vivo and in vitro drug metabolism in patients with leprosy.  a75-810 v54  aInfolep Library - available3 a<p>Plasma antipyrine and chloramphenicol clearance was studied in 23 patients of leprosy and 12 control subjects. Drug metabolising enzymes (aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase) were estimated in liver biopsy samples of twelve patients and ten controls. A significant decrease in drug clearance and drug metabolising enzymes was observed. However, no significant correlation could be obtained between drug half lives and drug metabolising enzymes or with any of the liver function tests in these patients. The findings indicate that drug metabolism is impaired in leprosy patients.</p>  a0024-1024