01380nas a2200301   4500000000100000008004100001260001300042653001200055653001300067653001200080653002100092653001100113653001200124653002200136653000900158653002500167653003100192100001300223700001400236700001500250700001800265245010600283856004100389300000900430490000700439520061800446022001401064       1982                            d  c1982 Mar10aAnimals10aBacteria10aDapsone10aEscherichia coli10aLasers10aleprosy10aMass Spectrometry10aMice10aMycobacterium leprae10aMycobacterium tuberculosis1 aSeydel U1 aLindner B1 aSeydel J K1 aBrandenburt K00aDetection of externally induced impairments in single bacterial cells by laser microbe mass analysis.  uhttp://ila.ilsl.br/pdfs/v50n1a13.pdf  a90-50 v503 a<p>Applying the laser microbe mass analyzer method (LAMMA), mass spectra (fingerprints) were taken from single bacterial cells not treated or treated with high temperature, X-irradiation, isonicotinic acid hydrazide (INH), or diaminodiphenylsulfone (DDS). Spectra of treated cells ("M. lufu," M. tuberculosis H37Ra, E. coli) differ from those of controls in that the K+/Na+ ratio was smaller and in that the intensities of peaks with m/e greater than 100 were lower. From the results with M. leprae the possible application of this new method for monitoring the effectiveness of leprosy therapy is proposed.</p>
  a0148-916X