01735nas a2200313   4500000000100000008004100001260001300042653002600055653001900081653002400100653002500124653002000149653003100169653001100200653001200211653001400223653001300237100001100250700001400261700001400275700001600289700001400305700001300319245009100332300001100423490000600434520096700440022001401407       1982                            d  c1982 Jul10aAntigens, Heterophile10aGene Frequency10aGenes, MHC Class II10aGenetics, Population10aHLA-DR Antigens10aHistocompatibility Testing10aHumans10aleprosy10aPhenotype10aSuriname1 aEden W1 aVries R R1 aD'Amaro J1 aSchreuder I1 aLeiker DL1 aRood J J00aHLA-DR-associated genetic control of the type of leprosy in a population from surinam.  a343-500 v43 a<p>The relationship between HLA phenotype and leprosy classification was studied in 73 unrelated patients and 92 healthy controls from a mixed Negroid-Caucasoid population originating from Surinam, South America. Heterogeneity in the distribution of HLA-DR (but not A, B, and C) was detected between tuberculoid (TT* + BT*) leprosy and lepromatous (BL* + LL*) leprosy patients (p = 0.024). This heterogeneity appeared to be caused almost exclusively by DR3. Most significantly, the frequency of DR3 was increased among polar tuberculoid (TT) leprosy patients as compared to the rest of the patients (p = 0.0003). Compared with healthy controls the frequency of DR3 was increased among TT patients (p = 0.006), unchanged in BT patients, and decreased among lepromatous (BL + LL) patients (p = 0.027). These data indicate that in this population an DR3-associated factor controls the type of the disease that develops after infection with Mycobacterium leprae.</p>  a0198-8859