01532nas a2200301   4500000000100000008004100001260001600042653002400058653002400082653001800106653001600124653001900140653001100159653002800170653002400198653004800222653003000270653002300300653002700323653003400350100001300384700001800397245008200415300000900497490000700506520070300513022001401216       1999                            d  c1999 Jun 0110aAmino Acid Sequence10aAntigens, Bacterial10aChaperonin 1010aDNA Primers10aDNA, Bacterial10aHumans10aMolecular Sequence Data10aMycobacterium avium10aMycobacterium avium subsp. paratuberculosis10apolymerase chain reaction10aSequence Alignment10aSequence Analysis, DNA10aSequence Homology, Amino Acid1 aCobb A J1 aFrothingham R00aThe GroES antigens of Mycobacterium avium and Mycobacterium paratuberculosis.  a31-50 v673 a<p>The GroES antigen provokes a strong immune response in human beings with tuberculosis or leprosy. We cloned and sequenced the Mycobacterium avium and Mycobacterium paratuberculosis GroES genes. M. avium and M. paratuberculosis have identical GroES sequences which differ from other mycobacterial species. This supports the current formal designation of M. paratuberculosis as M. avium subsp. paratuberculosis. Immunodominant epitopes from Mycobacterium tuberculosis GroES are conserved in M. avium, but some Mycobacterium leprae epitopes are distinct. GroES is unlikely to be specific as a serologic or skin test reagent, but may be an appropriate component of a broad mycobacterial vaccine.</p>  a0378-1135