01468nas a2200349   4500000000100000008004100001260001300042653001500055653001400070653002200084653002000106653001100126653001800137653001400155653001200169653002500181653002500206653002800231653001300259653003200272653000900304100001200313700001500325700001200340700001600352245011600368856007800484300001000562490000800572520052400580022001401104       1999                            d  c1999 Jul10aAntibodies10aApoptosis10aCalcium Signaling10aCells, Cultured10aHumans10aInterleukin-210aIonomycin10aleprosy10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aLeukocytes, Mononuclear10aMonensin10aTumor Necrosis Factor-alpha10aZinc1 aGupta A1 aSharma V K1 aVohra H1 aGanguly N K00aInhibition of apoptosis by ionomycin and zinc in peripheral blood mononuclear cells (PBMC) of leprosy patients.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905487/pdf/cei0117-0056.pdf  a56-620 v1173 a<p>PBMC from tuberculoid (BT/TT) and lepromatous leprosy (BL/LL) leprosy patients showed spontaneous apoptosis when cultured in the absence of mitogen for 24 h, which was inhibited by anti-tumour necrosis factor-alpha (TNF-alpha) antibodies. Apoptosis was also inhibited by ionomycin and zinc, which also increased IL-2 and decreased TNF-alpha production. The increase in IL-2 production suggests a mechanism whereby dietary supplements with zinc might alter the cell-mediated immunity response in leprosy patients.</p>  a0009-9104