02123nas a2200313   4500000000100000008004100001260001300042653003100055653002300086653002400109653001200133653001100145653002100156653002100177653002100198653001200219653002500231653002100256100001300277700001300290700001200303245015300315856004100468300001100509490000700520050001500527520125300542022001401795       1982                            d  c1982 Sep10aAntibodies, Anti-Idiotypic10aAntibody Formation10aAntigens, Bacterial10aDapsone10aHumans10aImmunoglobulin A10aImmunoglobulin G10aImmunoglobulin M10aleprosy10aMycobacterium leprae10aRadioimmunoassay1 aMelsom R1 aHarboe M1 aNaafs B00aClass specific anti-Mycobacterium leprae antibody assay in lepromatous leprosy (BL-LL) patients during the first two to four years of DDS treatment.  uhttp://ila.ilsl.br/pdfs/v50n3a01.pdf  a271-810 v50  aMELSOM19823 a<p>Previously, a slight decrease in antibodies against M. leprae antigen 7 was demonstrated after one year of dapsone (DDS) treatment in 14 of 15 patients with lepromatous (BL-LL) leprosy. The same patients have now received DDS from 11/2 to 4 years (median 3 years) and sera taken at the start, during, and at the end of the observation period have been retested for antibodies against M. leprae antigen 7 by radioimmunoassay and tested for IgA-, IgM-, and IgG-anti-M. leprae antibody activity by solid phase radioimmunoassay. Both IgA- and IgG-anti-M. leprae antibody activity and the activity of antibodies against M. leprae antigen 7 showed a decrease in activity after three years of DDS treatment to a median value of about one third of the activity in the sera taken at the start of the study. A smaller but significant decrease in IgM-anti-M. leprae antibody activity could be demonstrated. A transient increase in antibody activity (both measured by RIA and sRIA) could be demonstrated and related to reactions (reversal reaction and ENL) in five patients. No significant correlation could be found when IgA-, IgM-, and IgG-anti-M. leprae antibody activity was compared with antibodies against M. Leprae antigen 7 in individual sera.</p>
  a0148-916X