01401nas a2200301   4500000000100000008004100001260001300042653001200055653001500067653002000082653001900102653002100121653001100142653001200153653001800165653002500183653001300208653002200221100001300243700002000256700001600276245015800292300001000450490000700460050003200467520058600499022001401085       1982                            d  c1982 Oct10aAnimals10aArmadillos10aCorynebacterium10aDNA, Bacterial10aGenes, Bacterial10aHumans10aleprosy10aMycobacterium10aMycobacterium leprae10aNocardia10aSpectrophotometry1 aIMAEDA T1 aKirchheimer W F1 aBarksdale L00aDNA isolated from Mycobacterium leprae: genome size, base ratio, and homology with other related bacteria as determined by optical DNA-DNA reassociation.  a801-80 v54  aInfolep Library - available3 a<p>DNA derived from Mycobacterium leprae (grown in armadillos) was isolated, purified, and analyzed spectrophotometrically. The genome size and guanine-plus-cytosine content of M. leprae were 1.3 X 10(9) and 55.8%, respectively. Among selected strains of mycobacterial, nocardial and corynebacterial species, Corynebacterium sp. 2628 LB, isolated from a human leprosy patient, showed the highest DNA homology with M. leprae. Of the DNAs derived from mycobacteria, those of M. tuberculosis and M. scrofulaceum showed a comparatively high reassociation with the DNA of M. leprae.</p>  a0024-1024