01309nas a2200229   4500000000100000008004100001260001300042653001900055653001000074653001100084653001900095653001200114653001600126100001600142700001600158245007300174856004100247300001000288490000700298520076000305022001401065       1983                            d  c1983 Mar10aAdrenal Glands10aAdult10aHumans10aHydrocortisone10aleprosy10aMiddle Aged1 aBalybin E S1 aNAZAROV K I00aHydrocortisone production in lepromatous patients with insulin load.  uhttp://ila.ilsl.br/pdfs/v51n1a03.pdf  a18-210 v513 a<p>Hydrocortisone production was studied in 36 patients with lepromatous leprosy before and after insulin load as a stress factor using a competitive radioassay. Twenty-three patients showed a so-called paradoxical type of hydrocortisone production suggestive of markedly exhausted hydrocortisone-producing function of the adrenal cortex. Reserve hydrocortisone production was depressed in most of the patients with active disease; while cured patients showed a partial restoration in reserve hydrocortisone production. Leprosy relapses seem to be among the factors affecting the reserve hydrocortisone-producing function of adrenals. The question of reassessment of the principles of steroid therapy in lepromatous patients with relapses is raised.</p>
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