01590nas a2200265   4500000000100000008004100001260001700042653001000059653001100069653001100080653002100091653002300112653001200135653002600147653000900173653001600182653001100198100001900209700002300228700002000251245009300271300001000364490000700374520094300381       1984                            d  c1984 Mar-Apr10aAdult10aFemale10aHumans10aImmune Tolerance10aImmunity, Cellular10aleprosy10aLymphocyte Activation10aMale10aMiddle Aged10aPlasma1 aRamos Zepeda R1 aGonzalez Mendoza A1 aMorales Ortiz R00aDepressive effect of plasma on lymphocyte transformation in nodular lepromatous leprosy.  a182-90 v773 a<p>Lymphocytes from 20 patients with NLL were cultured stimulated with PHA in presence of autologous and homologous plasma; the same procedure was carried out with lymphocytes from 20 healthy people, utilized as controls. A diminished capacity of transformation was noticed when lymphocytes, both from patients and controls, were cultured in plasma from NLL patients, this suggesting the presence of a plasmatic inhibitor factor. This effect was particularly noticeable in 8 cases (40%) of the studied patients. Regarding the nature of the plasmatic factor, the concentration of C reactive protein, rheumatoid factor, alpha, beta and gamma globulins, did not show any correlation with the presence of the depressive activity. It seems that at least in some cases, the impaired lymphocyte transformation observed in NLL patients, can be due to an immune complex present as a plasma factor, rather to an intrinsic defect in lymphocytes.</p>