01700nas a2200337   4500000000100000008004100001260001700042653001000059653002500069653001100094653001000105653001100115653003700126653001200163653000900175653001600184653001400200653003700214653001700251653003200268653001500300100001100315700001400326700001400340700001400354245011100368300001000479490000700489520085200496022001401348       1978                            d  c1978 Jul-Aug10aAdult10aDinitrochlorobenzene10aFemale10aFetus10aHumans10aImmunologic Deficiency Syndromes10aleprosy10aMale10aMiddle Aged10aPregnancy10aStreptodornase and Streptokinase10aThymus Gland10aTransplantation, Homologous10aTuberculin1 aSaha K1 aDutta R N1 aDutta A K1 aMohan T K00aReversal reaction in patients with lepromatous leprosy after transplantation of human fetal thymic grafts.  a81-900 v353 a<p>An attempt has been made to reconstitute impaired cell-mediated immunity in 1 patient with indeterminate, 4 patients with borderline and 2 patients with polar lepromatous leprosy by grafting three thymus glands obtained from human fetuses of 14--19 weeks gestation. Most of these patients had severe ulcerative erythema nodosum leprosum (ENL) and were intolerant to dapsone. After thymus transplantation these patients were followed for 1 1/2 years. During this period, all conventional chemotherapy had been withdrawn. In most cases, there was dramatic improvement of the clinical condition, resolution of skin lesions, subsidence of ENL, clearance of bacteria from skin and reconstitution of several immunologic deficits; but late lepromin reactivity returned in none, which indicated permanent lose of resistance to Mycobacterium leprae.</p>  a0042-9007