01715nas a2200325   4500000000100000008004100001260001300042653001900055653001300074653001100087653001400098653001000112653001100122653001400133653001200147653002200159653001400181653004000195653002400235653001500259653002600274100001600300700001400316245006200330856004100392300000900433490000700442520092600449022001401375       1999                            d  c1999 Mar10aCohort Studies10aEthiopia10aFemale10aFertility10aFetus10aHumans10aLactation10aleprosy10aPostpartum Period10aPregnancy10aPregnancy Complications, Infectious10aProspective Studies10aRecurrence10aRetrospective Studies1 aLockwood DN1 aSinha H H00aPregnancy and leprosy: a comprehensive literature review.  uhttp://ila.ilsl.br/pdfs/v67n1a02.pdf  a6-120 v673 a<p>The interaction between pregnancy, leprosy and leprosy reactions was examined in a systematic literature review. Several retrospective case series and one retrospective cohort study but only one prospective cohort study were identified in the English literature. Type 1 (reversal) reactions were particularly likely to occur during the post partum. This temporal association was also present for both overt and silent neuritis. Type 2 (erythema nodosum leprosum) reactions occur throughout pregnancy and during lactation, and may be severe and recurrent. No prospective, controlled studies were found that documented the complications of pregnancy in women treated with multidrug therapy regimens. Our study highlights the need for such studies, with appropriate controls, on women throughout pregnancy and lactation so that risk factors for reaction and neuritis during pregnancy can be identified and quantified.</p>  a0148-916X