01462nas a2200325   4500000000100000008004100001260001300042653001000055653001200065653002500077653001100102653001400113653001300127653001200140653000900152653001300161653001800174653001500192653002000207100001500227700001200242700001600254700001700270245010400287300001000391490000700401050003200408520068200440022001401122       1983                            d  c1983 Apr10aAdult10aDapsone10aDinitrochlorobenzene10aHumans10aIrritants10aLepromin10aleprosy10aMale10aNeuritis10aNitrobenzenes10aSkin Tests10aTuberculin Test1 aMalhotra B1 aDas K D1 aTutakne M A1 aAggarwal S K00aPrecipitation of type-I (upgrading) reaction in leprosy by skin testing with antigen and irritants.  a305-90 v55  aInfolep Library - available3 a<p>Twenty patients of various types of leprosy were skin tested with lepromin, PPD and DNCB to assess their immunological status. Two of the twenty (18 BT; 2 BB) patients belonging to BT type developed signs of acute neuritis of sudden onset about 4 weeks after the test with DNCB, lepromin and PPD. The patients were on DDS therapy already for the last 3-4 months. Presumably DNCB, PPD or lepromin testing had precipitated the reaction. A suggestion is made that lepromin a lower concentration could be used initially and if it gives negative reaction, a higher concentration may be used as in case of PPD testing, particularly in TT and BT cases already put on treatment.</p>  a0024-1024