01421nas a2200325   4500000000100000008004100001260001300042653002500055653002500080653003200105653001400137653001900151653001600170653001200186653001100198653001200209653001000221653002500231100001500256700001500271700001500286700001400301700001900315245007900334300001000413490000700423050003200430520061900462022001401081       1983                            d  c1983 Oct10aAlanine Transaminase10aAlkaline Phosphatase10aAspartate Aminotransferases10aBilirubin10aBlood Proteins10aClofazimine10aDapsone10aHumans10aleprosy10aLiver10aLiver Function Tests1 aBulakh P M1 aKowale C N1 aRanade S M1 aBurte N P1 aChandorkar A G00aThe effect of clofazimine on liver function tests in lepra reaction (ENL).  a714-80 v55  aInfolep Library - available3 a<p>Twenty patients with suspected DDS resistance and repeated attacks of lepra reactions were selected for the study. Clofazimine was administered in different doses over a period of 12 months. Elevated levels of transaminases and Alkaline phosphatase prior therapy attained values to near normalcy. Progressive fall in serum Bilirubin and Proteins with normal A/G ratio at the end of therapy was also observed. Clofazimine by its anti-inflammatory and antibacterial action could inhibit the process of liver damage and happened to have minimal deleterious effect on liver by studying the liver function tests.</p>  a0024-1024