01249nas a2200289   4500000000100000008004100001260001300042653001500055653001000070653002400080653001000104653002100114653001100135653001100146653001200157653000900169653001600178100001400194700001700208700001400225245007600239300000900315490000700324050003200331520058200363022001400945       1983                            d  c1983 Jan10aAdolescent10aAdult10aAlpha 1-Antitrypsin10aChild10aErythema Nodosum10aFemale10aHumans10aleprosy10aMale10aMiddle Aged1 aYemul V L1 aSengupta S R1 aDhole T N00aProtease inhibitors activity in lepromatous leprosy and lepra reaction.  a91-40 v55  aInfolep Library - available3 a<p>Serum alpha one antitrypsin levels were measured in 50 healthy age and sex matched controls with 45 lepromatous leprosy cases and 5 cases of lepra reaction. It was noted that the mean level in healthy controls was 281.00 mg%, while the mean levels in LL patients was 421.00 mg% and in LR 570.00 mg%. The elevation of Alpha one antitrypsin was statistically significant in LL patients. It is possible that the rise is a reaction to release of proteases and or higher complement activity, which are the results of a high bacillary loading to formation of immune complexes.</p>  a0024-1024