01363nas a2200229   4500000000100000008004100001260001300042653004100055653001100096653002300107653001200130653002600142100001700168700001400185700001400199245009500213300001000308490000700318050003200325520076200357022001401119       1983                            d  c1983 Apr10aHistocompatibility Antigens Class II10aHumans10aImmunity, Cellular10aleprosy10aLymphocyte Activation1 aSengupta S R1 aYemul V L1 aDhole T N00aLymphocyte transformation test in lepromatous leprosy patients and their healthy siblings.  a261-40 v55  aInfolep Library - available3 a<p>Lymphoproliferative response to M. leprae, PHA, PPD and mixed leucocyte culture (MLC) were measured in 20 cases of lepromatous leprosy, 17 of their normal healthy siblings and 15 healthy controls. 7 siblings of LL patients were HLA-D identical, which was identified by doing MLC reaction. All healthy siblings including HLA-D identical responded normal to all stimulating agents including M. leprae antigen. In contrast 20 cases of LL responded very poorly to M. leprae antigen and almost near normal to other stimulating agents. The specific unresponsiveness of LL patients to M. leprae antigen does not result from an HLA linked genetic defect and the defective CMI response to M. leprae antigen seems to be acquired and not genetically determined.</p>  a0024-1024