01574nas a2200301   4500000000100000008004100001260001300042653001500055653001000070653002400080653001000104653001100114653001100125653001200136653000900148653001600157100001700173700001400190700001900204700001400223700001600237245006300253300001000316490000700326050003200333520089300365022001401258       1983                            d  c1983 Apr10aAdolescent10aAdult10aAlpha 1-Antitrypsin10aChild10aFemale10aHumans10aleprosy10aMale10aMiddle Aged1 aSengupta S R1 aDhole T N1 aJahagirdar V L1 aYemul V L1 aChawhan R N00aStudy of alpha one antitrypsin activity in lepra reaction.  a242-60 v55  aInfolep Library - available3 a<p>In our earlier study (Yemul et, al, 1983) we have reported elevation of serum alpha one antitrypsin levels in patients of lepromatous leprosy and lepra reaction. In this study estimation of serum alpha one antitrypsin levels in fifty lepra reaction patients (8 of type 1 and 42 of type II) and fifty age and sex matched healthy controls is described. Alpha one antitrypsin levels were elevated in lepra reaction patients (type I--mean value of 332 mg% and S.D. +/- 118.8 and type II--mean value of 450 mg% and S.D. +/- 73.7) when compared with the healthy controls (mean value of 285 mg% and S.D. +/- 66.05). The increase in levels in type II lepra reaction patients was statistically significant. The results are discussed to correlate the increased levels of alpha one antitrypsin and the high bacterial load leading to the release of various proteases in type II lepra reaction.</p>  a0024-1024