01464nas a2200325   4500000000100000008004100001260001300042653001800055653001200073653001100085653001100096653001300107653001200120653002000132653002600152653000900178653002400187653001800211100001200229700001600241700001100257700001600268700002000284245011100304300001100415490000700426050003200433520065900465022001401124       1983                            d  c1983 Jul10aB-Lymphocytes10aDapsone10aFemale10aHumans10aLepromin10aleprosy10aLeukocyte Count10aLymphocyte Activation10aMale10aPhytohemagglutinins10aT-Lymphocytes1 aKumar B1 aGanguly N K1 aKaur S1 aVaishnavi C1 aChakravarti R N00aEffect of dapsone (DDS) on T-cells and their response to PHA and lepromin in tuberculoid leprosy patients.  a465-710 v55  aInfolep Library - available3 a<p>T and B cell counts and their response to PHA and lepromin were studied in 46 patients of polar tuberculoid leprosy (TT), divided into two age and sex matched groups. Twenty five normal healthy controls were similarly investigated. While one group consisted of 26 untreated TT patients, the other included 20 individuals who had taken dapsone, 50 mg daily, for 12 to 14 months. There was significant decrease in the number of T-lymphocytes and their response to PHA and lepromin was lower in the treated, as compared to the untreated patients and normal persons. No significant change was found in the number of B-lymphocytes in any of the groups.</p>  a0024-1024