01416nas a2200301   4500000000100000008004100001260001700042653002100059653002200080653001100102653001200113653000900125653000900134653001600143100001900159700001400178700001500192700001300207700001500220700001700235700001300252245007300265300001000338490000700348050003200355520071300387022001401100       1984                            d  c1984 Apr-Jun10aErythema Nodosum10aHematologic Tests10aHumans10aleprosy10aMale10aSkin10aThalidomide1 aChandorkar A G1 aBurte N P1 aJadhav J H1 aGade R K1 aBulakh P M1 aTayshete S N1 aKale V M00aThalidomide in lepra reaction (ENL) in lepromatous leprosy patients.  a264-80 v56  aInfolep Library - available3 a<p>Six male bacteriologically highly positive patients of lepromatous leprosy with ENL reaction not adequately controlled by conventional antireaction drugs were put on thalidomide 400 mg per day in four divided doses. Reaction was controlled between 13th to 18th day of therapy. There was no change in the bacteriological status. Liver functions, renal functions and hemogram were normal before therapy and remained unaltered at the end of treatment. Apart from fatigue, drowsiness and occassional constipation, thalidomide had no adverse effect. Control of ENL reaction by thalidomide in these patients is probably due to its immunosuppressive effect, more likely by its stablising action on lysosomes.</p>  a0254-9395