01401nas a2200325   4500000000100000008004100001260001300042653001000055653000900065653001100074653002200085653002100107653001100128653001100139653002000150653001200170653002000182653002600202653000900228653001500237653001800252653001700270100001800287700001700305245007300322300001000395490000700405520064900412022001401061       1984                            d  c1984 Jun10aAdult10aAged10aBiopsy10aBlood Transfusion10aErythema Nodosum10aFemale10aHumans10aImmunoglobulins10aleprosy10aLeukocyte Count10aLeukocyte Transfusion10aSkin10aSkin Tests10aT-Lymphocytes10aTime Factors1 aMartínez M I1 aSánchez J L00aTreatment of leprosy with weekly intravenous infusion of leukocytes.  a341-70 v233 a<p>Two patients with lepromatous leprosy were treated with weekly intra-venous infusions of leukocyte concentrates for a period of 12 consecutive weeks. A reversal reaction was induced in one of the patients, and it was possible to control chronic erythema nodosum leprosum in the other subject. Possible pathogenetic mechanisms involved in the induction of these changes include the action of transfer factor, interactions between B- and T-lymphocytes or the mediation of a lymphokine necessary for the effective function of the cell-mediated immunity. Immunotherapy for chronic infections, such as leprosy, still has not become a reality.</p>  a0011-9059