01437nas a2200253   4500000000100000008004100001260001300042653001700055653002000072653004100092653001100133653001200144653001400156100001800170700001700188700001400205700001300219700001300232245011100245300000900356490000700365520079700372022001401169       1984                            d  c1984 Jul10aHLA Antigens10aHLA-DR Antigens10aHistocompatibility Antigens Class II10aHumans10aleprosy10aVenezuela1 aOttenhoff T H1 aGonzalez N M1 aVries R R1 aConvit J1 aRood J J00aAssociation of HLA specificity LB-E12 (MB1, DC1, MT1) with lepromatous leprosy in a Venezuelan population.  a25-90 v243 a<p>To investigate whether an association could be found between HLA and lepromatous leprosy a population study was performed in Tachira, Venezuela. This was done in the same endemic area in which recently both non-random parental HLA-haplotype and preferential segregation of the HLA specificity LB-E12 (MB1, DC1, MT1) was demonstrated in lepromatous leprosy patients from multicase families. In this study 32 lepromatous patients and 32 healthy controls were typed for HLA-A, -B, -C, -DR and the specificities MB and MT. The frequency of LB-E12 (MB1, DC1, MT1) showed a significant increase in lepromatous leprosy patients (p = 0.04). This is the first report concerning HLA and leprosy which confirms in the same endemic area an association observed in families on the population level.</p>  a0001-2815