01313nas a2200277   4500000000100000008004100001260001700042653001100059653002100070653001200091653002500103653000900128100001500137700001600152700001500168700001500183700001500198700001500213700001800228245006900246300001000315490000700325050003200332520065700364022001401021       1984                            d  c1984 Oct-Dec10aHumans10aLangerhans Cells10aleprosy10aMicroscopy, Electron10aSkin1 aMathur N K1 aAgarwal U S1 aMangal H N1 aBedwal R S1 aMathur R S1 aBajpai V K1 aShipstone A C00aUltrastructural study of epidermal Langherhans cells in leprosy.  a840-30 v56  aInfolep Library - available3 a<p>ATPase staining and ultrastructural study of skin biopsies from six patients of leprosy (2TT, 4LL) and three normal subjects was carried out to study Langherhans Cells (LC). ATPase staining showed normal counts of LCs in tuberculoid patients, while significant reduction was observed in lepromatous cases. Electron microscopy revealed morphological changes in LL cases in the form of dense matrix and indistinct cristae of mitochondria; decreased number of lysosomes and rough endoplasmic reticulum; and numerous vacuoles in cytoplasm. TT cases showed normal morphology. Possible role of Langerhans Cells in pathogenesis of leprosy is discussed.</p>  a0254-9395