01634nas a2200277   4500000000100000008004100001260001300042653001500055653001600070653001100086653000900097653001200106653000900118653001800127653002000145653001700165653001700182100001400199700001200213245010500225300001000330490000700340050003200347520096300379022001401342       1978                            d  c1978 Jan10aFolic Acid10aHemoglobins10aHumans10aIron10aleprosy10aMale10aSerum Albumin10aSerum Globulins10aTime Factors10aVitamin B 121 aKarat A B1 aRao P S00aHaematological profile in leprosy. Part II--Relationship to severity of disease and treament status.  a18-250 v50  aInfolep Library - available3 a<p>321 adult male lepromatous leprosy patients were studied for relationship between haematological findings, severity of disease and duration of treatment. Significant changes were noticed in relation in haemoglobin concentration, serum vitamin B12 and serum folate levels, serum albumin and globulin. No significant changes were observed in serum iron levels in relation to disease and treatment status. With rising bacterial load, there was a trend towards lower haemoglobin concentration, higher vitamin B12 level and lowered serum folate levels. Serum albumin showed a significant decline, while serum globulin showed a significant rise. The findings are discussed in relation to replacement of bone marrow by lepromatous tissue as well as possible interference in the metabolism of haematinics by M. leprae. The exact mechanism of neurlogical deficit in leprosy in relation to deficiency of vitamin B12 and folic acid need to be further elucidated.</p>  a0024-1024