01491nas a2200289   4500000000100000008004100001260001300042653002400055653001900079653004100098653001100139653002300150653001200173653002600185653001600211653002500227653003000252100001100282700001300293700001400306700001500320245017500335300001100510490000700521520065900528022001401187       1980                            d  c1980 Nov10aAntigens, Bacterial10aConcanavalin A10aHistocompatibility Antigens Class II10aHumans10aImmunity, Cellular10aleprosy10aLymphocyte Activation10aMacrophages10aMycobacterium leprae10aT-Lymphocytes, Regulatory1 aNath I1 aRood J J1 aMehra N K1 aVaidya M C00aNatural suppressor cells in human leprosy: the role of HLA-D-identical peripheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses.  a203-100 v423 a<p>Six families with HLA-D-identical siblings suffering from leprosy were studied. Lymphocytes and macrophages isolated from the peripheral blood were co-cultured with allogeneic, HLA-D-identical cells and stimulated with M. leprae antigens and concanavalin A. Tuberculoid patients had circulating lymphocytes which showed marked functional suppression of lymphoproliferative responses to antigen and mitogen. In contrast, lepromatous patients showed weak lymphocyte suppressor activity. Macrophages derived from responder individuals augmented, while those derived from lepromatous patients inhibited, M. leprae-induced proliferation of lymphocytes.</p>  a0009-9104