01478nas a2200277   4500000000100000008004100001260001300042653002900055653001100084653002100095653002300116653001100139653002800150653001100178653001200189653000900201653001600210100001100226700001700237700001000254245003500264300001000299490000700309520087000316022001401186       1981                            d  c1981 Sep10aAntigen-Antibody Complex10aBiopsy10aErythema Nodosum10aGlomerulonephritis10aHumans10aImmune Complex Diseases10aKidney10aleprosy10aMale10aMiddle Aged1 aNg W L1 aScollard D M1 aHua A00aGlomerulonephritis in leprosy.  a321-90 v763 a<p>A renal biopsy from a patient with lepromatous leprosy but no history of erythrema nodosum leprosum (ENL) showed histologic, immunofluorescent, and ultrastructural features typical of immune-complex glomerulonephritis. A literature review found reports of 187 renal biopsies from leprosy patients, with glomerulonephritis in 31% of the cases, and a variety of other renal lesions. This accumulated evidence demonstrates that, contrary to widely held opinion, there is no association between glomerulonephritis and a history of ENL. Furthermore, it suggests that glomerulonephritis in leprosy patients has a similar incidence in lepromatous and non-lepromatous cases. These observations have an important bearing on concepts regarding the pathogenesis of immune complex glomerulonephritis in leprosy and the humoral immune mechanisms in patients with leprosy.</p>  a0002-9173