01909nas a2200349   4500000000100000008004100001260000900042653001200051653003100063653002600094653001100120653002700131653001300158653001600171653001100187653002000198653002900218653001200247653000900259653001200268653000900280653001000289653001300299100001300312700001100325700001400336245013100350300001100481490000700492520104600499022001401545       1983                            d  c198310aAnimals10aAntigen-Antibody Reactions10aAntigens, Heterophile10aCattle10aChemical Precipitation10aChickens10aGuinea Pigs10aHumans10aImmunodiffusion10aInfectious Mononucleosis10aleprosy10aMice10aRabbits10aRats10aSheep10aSyphilis1 aMorito T1 aKano K1 aMilgrom F00aStudies on the Paul-Bunnell antigen-antibody system. III. Detection of a Paul-Bunnell-related antigen in syphilis and leprosy.  a117-210 v713 a<p>By means of double-diffusion precipitation tests in agarose gel with selected infectious mononucleosis (IM) sera, an antigen was detected in sera of patients with syphilis and leprosy. Of 378 syphilis sera tested 39 (10.3%) and of 36 leprosy sera 7 (19.4%) gave positive results. Sera of patients with various other diseases were negative. This antigen was demonstrable in sera of patients with both early and late syphilis and was shown to be unrelated to cardiolipin. Absorption studies of the IM sera with bovine and sheep erythrocytes and guinea pig tissues revealed that this antigen was identical with or closely related to the previously described B antigen of the Paul-Bunnel (P-B) antigenic complex and distinct from heterophile antigens of Hanganutziu-Deicher (H-D) and of Forssman specificity. However, 2 of 89 syphilis sera without the P-B antigen were shown to contain antigen(s) of H-D specificity. None of the syphilis or the leprosy sera contained P-B antibodies, but H-D antibodies were found in 13% of syphilis sera.</p>  a0020-5915