01934nas a2200277   4500000000100000008004100001260001300042653002400055653002000079653004100099653003100140653001100171653001200182653001500194653002000209100001100229700001400240700001700254700001300271245009600284856009000380300001100470490000700481520115400488022001401642       1983                            d  c1983 May10aGenes, MHC Class II10aHLA-DR3 Antigen10aHistocompatibility Antigens Class II10aHistocompatibility Testing10aHumans10aleprosy10aTuberculin10aTuberculin Test1 aEden W1 aVries R R1 aStanford J L1 aRook G A00aHLA-DR3 associated genetic control of response to multiple skin tests with new tuberculins.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1535848/pdf/clinexpimmunol00158-0051.pdf  a287-920 v523 a<p>Multiple skin testing with mycobacterial antigenic preparations reveals distinct reaction patterns, which might be relevant to the development of mycobacterial disease in man. Previous work has shown that HLA-DR associated factors correlate with the position of a leprosy patient in the immunopathological spectrum of leprosy. This study was undertaken to see whether these skin test patterns in healthy persons do show any association with HLA-DR types. Out of a group of 74 healthy Caucasoid individuals HLA-DR3 was observed to be absent from the 16 individuals who did not respond to any of the mycobacterial antigens tested. This is a striking difference from the distribution of HLA-DR3 both among the 17 individuals who responded to all mycobacterial antigens tested (P = 0.005) and the 41 individuals who responded to some but not all antigens (P = 0.015). These data show that an HLA-DR3 associated genetic factor controls, albeit indirectly, skin test responsiveness to mycobacterial antigens. It may be significant that this same HLA-DR determinant is implicated in deciding the type of disease to be developed by a leprosy patient.</p>  a0009-9104