01168nas a2200313   4500000000100000008004100001260001600042653001000058653001600068653001200084653003000096653001100126653001200137653002000149653000900169653002000178653001300198653001800211100001200229700001200241700001400253700001700267700001500284245006800299300001100367490000800378520045400386022001400840       1984                            d  c1984 Dec 1510aAdult10aClofazimine10aDapsone10aDrug Therapy, Combination10aHumans10aleprosy10aLeukocyte Count10aMale10aPlasma Exchange10aRifampin10aT-Lymphocytes1 aLucht F1 aRifle G1 aPortier H1 aChalopin J M1 aBonhomme J00aSuccessful plasma exchange in type 1 leprosy reversal reaction.  a1647-80 v2893 a<p>A 24 year old man admitted to hospital with borderline lepromatous leprosy was treated with rifampicin, dapsone, and clofazimine. After four months he developed a reversal reaction and the diagnosis was modified to borderline tuberculoid leprosy. The dose of clofazimine was raised and prednisolone added to the regimen without any symptomatic response. His condition improved dramatically after five plasma exchanges on five successive days.</p>  a0267-0623