01060nas a2200253 4500000000100000008004100001260001700042653001200059653001100071653001100082653002300093653001200116653000900128653002500137653001400162100001500176700001600191700001500207245015300222300001000375490000600385520040100391022001400792 1983 d c1983 Oct-Dec10aAnimals10aBiopsy10aHumans10aLeprostatic Agents10aleprosy10aMice10aMycobacterium leprae10aSerotonin1 aFerracci C1 aBaquillon G1 aPattyn S R00a[Action of desoxyfructo-serotonin on Mycobacterium leprae. Results of inoculation of human biopsy specimens in the mouse after a year of treatment]. a233-50 v13 a

M. leprae, extracted from cutaneous biopsies of 4 out of 7 patients treated with DFS during one year at doses of 1000 to 1500 mg/day were injected in mouse foot pads. Bacterial multiplication was observed in each case. The purely bacteriostatic activity of DFS for M. leprae, previously observed in mice, is thus confirmed. The eventual place of DFS in the therapy of leprosy is discussed.

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