01243nas a2200241   4500000000100000008004100001260001700042653002600059653001200085653003100097653003000128653001100158653001200169653001300181653002500194653001700219100001400236245004700250300001000297490000700307520067300314022001400987       1984                            d  c1984 Jan-Mar10aAnti-Bacterial Agents10aDapsone10aDrug Resistance, Microbial10aDrug Therapy, Combination10aHumans10aleprosy10aMutation10aMycobacterium leprae10aTime Factors1 aGrosset J00a[Advances in the chemotherapy of leprosy].  a17-220 v443 a<p>The chemotherapy of multibacillary leprosy with dapsone alone has resulted after 15-20 years in the selection and the diffusion of dapsone resistant Mycobacterium leprae. To overcome dapsone resistance, to prevent the selection of organisms resistant to other drugs and to kill the largest proportion of sensitive M. leprae, the chemotherapy of leprosy must rely, as chemotherapy of tuberculosis, upon the combination of several drugs. Rifampicin is included in all drug combinations recommended by WHO. The drug combinations have to be given for at least six months in patients with paucibacillary leprosy and two years in patients with multibacillary leprosy.</p>  a0025-682X