01457nas a2200325   4500000000100000008004100001260001300042653002400055653002300079653002000102653001500122653004100137653002000178653001100198653001200209653001600221653001600237653001800253653002500271653001200296100001400308700001500322700001800337700001400355245007900369300001100448490000700459520065100466022001401117       1984                            d  c1984 Apr10aAntigens, Bacterial10aCell Communication10aCells, Cultured10aColchicine10aHistocompatibility Antigens Class II10aHLA-DR Antigens10aHumans10aleprosy10aLymphocytes10aMacrophages10aMycobacterium10aMycobacterium leprae10aTrypsin1 aBirdi T J1 aMistry N F1 aMahadevan P R1 aAntia N H00aAntigen specific macrophage-lymphocyte interaction in lepromatous leprosy.  a189-940 v133 a<p>Peripheral blood derived macrophages from lepromatous leprosy patients were unable to interact with lymphocytes in the presence of M. leprae. This lack of interaction is probably not associated with membrane HLA-Dr antigens since trypsin and colchicine restored M. leprae induced depression in the latter but were unable to bring about a positive interaction. Two possible defects exist therefore in the lepromatous macrophage. These are an innate inability to process and present M. leprae antigens to lymphocytes and an induced inability to express some membrane receptors, an event detrimental to the normal functioning of a macrophage.</p>  a0141-2760