01586nas a2200337   4500000000100000008004100001260001700042653001200059653002300071653001600094653003000110653002000140653001100160653001300171653001200184653001500196653000900211653002400220653001800244653002400262653002500286653001100311100001300322700001400335245009100349300001100440490000700451050003200458520074400490022001401234       1984                            d  c1984 Apr-Jun10aAnimals10aBacterial Vaccines10aBCG Vaccine10aCell Migration Inhibition10aCross Reactions10aFemale10aLepromin10aleprosy10aLeukocytes10aMice10aMice, Inbred BALB C10aMycobacterium10aMycobacterium avium10aMycobacterium leprae10aSpleen1 aKale V P1 aBAPAT C V00aAntigeneic cross-reactivity between ICRC-bacilli and M. leprae--"in vitro" evaluation.  a219-310 v56  aInfolep Library - available3 a<p>Leucocyte migration inhibition, in presence of specific particulate antigen, is a good correlate of CMI. It can detect small differences in related antigens. In the present study, LMI was used to study the cross-reactivity between ICRC bacilli and M. leprae and also to examine the antigenic relationship amongst different ICRC isolates. The study showed a close antigenic cross-reactivity in lepromin and ICRC-in. LMI has brought out strain differences in two ICRC culture isolates, C-44 and C-75. The data appear to elucidate the possible strain specific antigenic relationship of M. leprae with its culture isolate e.g. ICRC strains. This may have important bearing on the development effective antileprosy vaccine for human use.</p>  a0254-9395