01203nas a2200301   4500000000100000008004100001260001300042653001800055653001100073653002100084653002300105653002400128653001200152653001600164653002500180653003000205653001800235100001600253700001400269700001200283700001800295700001400313245008000327300001000407490000700417520046300424022001400887       1984                            d  c1984 Jul10aCell Membrane10aHumans10aImmune Tolerance10aImmunity, Cellular10aIn Vitro Techniques10aleprosy10aMacrophages10aMycobacterium leprae10aReceptors, Concanavalin A10aReceptors, Fc1 aSalgame P R1 aBirdi T J1 aLad S J1 aMahadevan P R1 aAntia N H00aMechanism of immunosuppression in leprosy--macrophage membrane alterations.  a145-90 v143 a<p>L-Lysate induced macrophage membrane alteration was studied using 3 membrane markers: (i) Fc receptor, (ii) Concanavalin A (Con A) receptor, and (iii) M. leprae adherence to macrophage membrane. The data indicate that L-lysate induces membrane perturbation of normal macrophages. The alteration can be reversed with trypsin and colchicine. Membrane alteration observed may lead to defective macrophage participation in a cell-mediated immune reaction.</p>  a0141-2760