01664nas a2200361   4500000000100000008004100001260001300042653001200055653002600067653002900093653002300122653001800145653001900163653003000182653001100212653001200223653002500235653002100260653001200281653002200293100001900315700001400334700001100348700001300359700001300372700001500385700001300400245007100413300001000484490000700494520078700501022001401288       1984                            d  c1984 Sep10aAnimals10aAntibodies, Bacterial10aAntigen-Antibody Complex10aC-Reactive Protein10aComplement C310aComplement C3d10aComplement Fixation Tests10aHumans10aleprosy10aMycobacterium leprae10aPrecipitin Tests10aRabbits10aRheumatoid Factor1 aRamanathan V D1 aParkash O1 aRamu G1 aParker D1 aCurtis J1 aSengupta U1 aTurk J L00aIsolation and analysis of circulating immune complexes in leprosy.  a261-80 v323 a<p>Circulating immune complexes (CIC) were isolated by two antigen nonspecific methods from 60 leprosy patients belonging to borderline tuberculoid (BT) and lepromatous (LL) types with and without reactions. CIC were elevated in both BT and LL reactions. CIC from BT in reaction (BTR) were found to consist largely of IgG and C3, whereas, C-reactive protein could be found in CIC from LL reactions (LR). In addition, IgM and rheumatoid factor were demonstrated in the complexes of LR patients who had mainly arthritis. Antimycobacterial antibody was seen in the complexes of two-thirds of LR patients who had predominantly skin manifestations as part of their reaction. The relevance of these findings to the clinical manifestations of different types of reactions is discussed.</p>  a0090-1229