01225nas a2200253   4500000000100000008004100001260001700042653001200059653001200071653000900083653002500092653002500117100001600142700001100158700001200169700001600181700002000197245010500217300001000322490000700332050003200339520058600371022001400957       1984                            d  c1984 Oct-Dec10aAnimals10aleprosy10aMice10aMice, Inbred Strains10aMycobacterium leprae1 aVaishnavi C1 aKaur S1 aKumar B1 aGanguly N K1 aChakravarti R N00aTrophic changes and extensive dissemination in normal mice infected with human Mycobacterium leprae.  a742-70 v56  aInfolep Library - available3 a<p>Closely bred Swiss albino normal mice (Lecca Strain) were inoculated in the footpad with M. leprae, at room temperature. The animals were harvested at 3, 6 and 9 months post inoculation, and bacillary counts were made. Trophic changes were observed in the tail-tips, ears, footpads and forepaws 12-14 months post inoculation in a group which was allowed to survive. The histopathological changes and bacillary infiltration was found in many tissues/organs. The possibility of studying this normal strain of mice as an experimental model for human leprosy has been discussed.</p>  a0254-9395