01443nas a2200277   4500000000100000008004100001260001700042653002100059653002000080653001800100653001100118653001500129653002800144653001200172653001600184653001500200653002500215100001400240700001800254245009700272300001100369490000700380050003200387520073200419022001401151       1984                            d  c1984 Oct-Dec10aAcid Phosphatase10aCells, Cultured10aGlucuronidase10aHumans10aHydrolases10aL-Lactate Dehydrogenase10aleprosy10aMacrophages10aMuramidase10aMycobacterium leprae1 aMarolia J1 aMahadevan P R00aHydrolytic enzymes in macrophages from leprosy patients in presence of Mycobacterium leprae.  a776-830 v56  aInfolep Library - available3 a<p>Presence of Mycobacterium leprae in association with in vitro cultured macrophages, from bacillary negative long term treated lepromatous leprosy patients, induces reduced level of protein and lowering of hydrolytic enzymes like p-glucuronidase, Lysozyme and Lactic dehydrogenase. Alkaline phosphatase, on the other hand is increased. In the macrophages from normal healthy individuals or tuberculoid leprosy patients, presence of M.leprae increases both protein and levels of all the above enzymes. This observation shows that macrophages from lepromatous leprosy patients are unable to manifest in presence of M. leprae, the key enzymes involved in degradation of complex biological entities phagocytosed by the cells.</p>  a0254-9395