01817nas a2200337   4500000000100000008004100001260001300042653002700055653001200082653002400094653001100118653001600129653003000145653002300175653001700198653001200215653001600227653000900243653002100252653002500273653001600298100001400314700001100328700001400339700001300353245013600366300001000502490000700512520094600519022001401465       1984                            d  c1984 Dec10aAdjuvants, Immunologic10aAnimals10aAntigens, Bacterial10aFemale10aGlycolipids10aHypersensitivity, Delayed10aImmunity, Cellular10aInflammation10aleprosy10aLymph Nodes10aMice10aMice, Inbred CBA10aMycobacterium leprae10aVaccination1 aBrett S J1 aLowe C1 aPayne S N1 aDraper P00aPhenolic glycolipid 1 of Mycobacterium leprae causes nonspecific inflammation but has no effect on cell-mediated responses in mice.  a802-80 v463 a<p>The involvement of the phenolic glycolipid from Mycobacterium leprae in cell-mediated immunity has been investigated in this study. The phenolic glycolipid itself does not appear to stimulate cell-mediated immunity directly, as shown by its failure to elicit a classical delayed-type hypersensitivity response in mice immunized with M. leprae or to stimulate M. leprae-immune lymph node cells in a lymphoproliferative assay. Intradermal vaccination with the phenolic glycolipid failed to influence the growth of M. leprae in mouse footpads. A nonspecific inflammatory response to the sonicated glycolipid was observed in mice vaccinated with whole M. leprae and in control animals. No evidence was obtained for any adjuvant or suppressive effect on cell-mediated immunity by the phenolic glycolipid either to M. leprae or an unrelated antigen (sheep erythrocytes); neither sensitization nor elicitation to either antigen was affected.</p>  a0019-9567