02015nas a2200301   4500000000100000008004100001260000900042653002400051653002300075653002300098653001800121653001100139653001200150653002300162653002500185100001500210700001500225700001600240700001700256700001600273700001800289700001000307245007900317300001100396490000700407520128500414022001401699       1983                            d  c198310aAgglutination Tests10aAntibody Formation10aC-Reactive Protein10aCryoglobulins10aHumans10aleprosy10aLipoproteins, VLDL10aMycobacterium leprae1 aArruda M S1 aArruda O S1 aAstolfi C S1 aNogueira M E1 aBastazini I1 aOpromolla D V1 aUra S00a[The Rubino reaction. Criterion for inactivation in lepromatous patients].  a423-300 v113 a<p>Approximately 55% of active lepromatous patients respond positively to the Rubino reaction. With arrested cases this rate of positivity lowers considerably to about 15%. In an effort to associate this reaction with the presence of bacilli, a study of 796 cases was undertaken. The patients were divided into: a control group, active tuberculoid cases, arrested tuberculoid cases, active borderline cases, arrested borderline cases, active lepromatous cases, and arrested lepromatous cases. The patients were submitted to the following tests: Rubino reaction, presence of cryoglobulins, and VDRL and PCR positivity. By the results obtained we may conclude that: a) A positive Rubino reaction may be present in all the forms of leprosy studied, this reaction having an inverse relationship with the organism's resistance to "M. leprae". b) The Rubino reaction has specificity to leprosy. c) This reaction does not depend on the number of bacilli present in the host. d) A positive Rubino reaction is not related to the presence of cryoglobulins in the serum, nor to VDRL or PCR positivity, nor to the length of time the patient's disease has been arrested. The authors present these findings and suggest that this reaction be used as one of the criteria for determining cure.</p>  a0210-5187