01373nas a2200265   4500000000100000008004100001260001700042653001600059653001200075653003300087653003000120653001900150653001600169653001100185653002300196653001200219653001800231653001300249100002800262245004300290300001100333490000600344520074300350022001401093       1983                            d  c1983 Jul-Sep10aClofazimine10aDapsone10aDrug Administration Schedule10aDrug Therapy, Combination10aDrug Tolerance10aEthionamide10aHumans10aLeprostatic Agents10aleprosy10aProthionamide10aRifampin1 aTerencio de las Aguas J00a[Combination drug therapy in leprosy].  a143-500 v13 a<p>The importance of polichemotherapy in multibacilar leprosy (LL and LD) in patients without any previous therapy as in those diagnosticated and under monotherapy most of all in the resistance patients is presented. Sulphones, clofazimine and rifampicine are selected as first rate drugs and protionamide-etionamide as second rate drugs. The therapy plans with the association of two and three drugs and the convenience of continuing indefinitely with at least one of the drugs are presented insisting on the advantages of the clofazimine-sulphones and rifampicine-sulphones associations. The necessity of immunotherapy for recover of celular immunity against the bacilus, is the only form of preventing relapses and drug resistance.</p>  a0001-5938