01404nas a2200277   4500000000100000008004100001260001300042653001600055653001200071653003000083653001100113653001200124653002500136653000900161653001300170100001800183700001700201700001600218700001800234245008300252300001100335490000700346050003200353520072700385022001401112       1983                            d  c1983 Jul10aClofazimine10aDapsone10aDrug Therapy, Combination10aHumans10aleprosy10aMycobacterium leprae10aNose10aRifampin1 aPrabhakar M C1 aAppa Rao A V1 aKrishna D R1 aRamanakar T V00aHow much non-infectious are the "non-infectious" lepromatous leprosy patients?  a576-830 v55  aInfolep Library - available3 a<p>Nose forms an important site at which the M. leprae in lepromatous leprosy (LL) patients lodge and multiply. Nose forms an important reservoir for M. leprae, from where they may be transmitted to healthy contacts. Inspite of realizing the above fact, nose does not normally receive due importance during the chemotherapy of leprosy. LL patients, after regular treatment with dapsone or rifampin for about 20 wks and 3 wks respectively are normally considered non-infectious. From the present investigation it is clear that local treatment of the ones with a bactericidal agent should perhaps be necessary during chemotherapy of LL patients to make them non-infectious and to control the transmission of the disease.</p>  a0024-1024