01414nas a2200253   4500000000100000008004100001260000900042653001200051653002200063653002000085653001100105653001400116653002300130653001200153653001800165653001300183653001200196100002100208245004500229300001100274490000600285520085500291022001401146       1976                            d  c197610aDapsone10aDrug Combinations10aDrug Evaluation10aHumans10aIsoniazid10aIsonicotinic Acids10aleprosy10aProthionamide10aRifampin10aTablets1 aDe Las Aguas J T00a[New drugs in the treatment of leprosy].  a365-700 v43 a<p>Two groups of patients were chosen for this treatment; the first group of 14 patients was treated with a daily dose of 600 mg. of Rifampicine and the second group with Rifampicine associated with Isoprodian (1-2 tablets). In the first group clinical and bacteriological improvement was apparent. This was parallel in bacteriological and morphological index. Two patients became negative in nasal mucous. Tolerance was good and number of leprosy reactions 65%. In the second group clinical improvement was good in general but one case that presented a continuous polyneuritis and hepatic intolerance. Bacteriological results were lightly lower than the first group and the number of leprosy reactions 85%. This treatment is considered inferior to the sulfons, which is very expensive. A longer period of time will be needed to appriase results.</p>  a0210-5187