02063nas a2200325   4500000000100000008004100001260001300042653002400055653001800079653002000097653002000117653004100137653001100178653001300189653001200202653001400214653002500228653001800253100001100271700001700282700001400299700001400313700001300327245009800340856008900438300001000527490000700537520117900544022001401723       1984                            d  c1984 Jan10aAntigens, Bacterial10aCell Division10aCells, Cultured10aHLA-DR3 Antigen10aHistocompatibility Antigens Class II10aHumans10aLepromin10aleprosy10aMonocytes10aMycobacterium leprae10aT-Lymphocytes1 aEden W1 aElferink B G1 aVries R R1 aLeiker DL1 aRood J J00aLow T lymphocyte responsiveness to Mycobacterium leprae antigens in association with HLA-DR3.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1535784/pdf/clinexpimmunol00148-0149.pdf  a140-80 v553 a<p>The type of leprosy which develops after infection with Mycobacterium leprae is influenced by the presence or absence of HLA-DR3, as has been demonstrated in an ethnic group originating from Surinam. In the present study we investigated in this same ethnic group the role of HLA-DR, and of HLA-DR3 in particular, in monocyte-T cell interactions during leprosy specific proliferative responses in vitro. HLA-DR3 heterozygous T cells from tuberculoid leprosy patients were cultured with antigen and either HLA-DR3 positive or HLA-DR3 negative homozygous HLA-DR compatible allogeneic monocytes as antigen presenting cells (APCs). T cell proliferative responses with DR3 homozygous monocytes as APCs, were observed to be decreased as compared to T cell proliferative responses with DR3 negative homozygous monocytes as APCs. Furthermore, although the leprosy specific monocyte-T cell interactions were shown to be restricted for HLA-DR, in the anti-MLW-1 response HLA-DR3 appeared to function as a restricting element poorly or not at all. These observations may imply, that an in vitro correlate has been found for an (HLA associated) genetic control of leprosy in vivo.</p>  a0009-9104